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Nonetheless, with inconclusive analysis, taurine could be effective to the balance between the cytokine response and the anti-inflammatory response following exercise [69]. Taurine concentrations in cardiac mitochondria are estimated in high concentrations to be 70 nmoL/mg [26]). It has been suggested that higher concentrations of taurine in the cardiac mitochondria can inhibit mitochondrial apoptosis, oxidative and endoplasmic reticulum tension, and serve as a mitochondrial buffer [34]. The acyl-CoA dehydrogenases which control the β-oxidation of fatty acids are shown to have optimal activity with mitochondrial taurine serving as a mitochondrial buffering agent [26]. For instance 토토사이트, the rate of β-oxidation of endogenous fatty acids was 31% lower in the taurine-deficient heart in mice compared to the control heart [65]. Stabilizing the pH gradient in the mitochondrial matrix by the presence of taurine as a buffer is crucial for maintaining the biochemical processes. Taurine has also been demonstrated to be a constituent of modified uridine residues in mitochondrial tRNA [26]. The modified uridine residues in the mitochondria suggest that taurine may play a part in the mitochondrial matrix and be implicated in mitochondrial diseases such as cardiovascular disease.